Diffuse Large B Cell Lymphoma (DLBCL)



Diffuse Large B-Cell Lymphoma, or DLBCL for short, is the most common type of Non-Hodgkin's Lymphoma in adults. It is a type of B-cell lymphoma that affects lymph nodes spread diffusely throughout the body.  DLBCL can be caused by mutations in BCL-2 and BCL-6. As an aggressive cancer, DLBCL usually presents as a rapidly-enlarging mass in patients. Important to remember is the fact that DLBCL can arise from CLL, in a process known as a Richter transformation -- in which CLL turns into the more aggressive DLBCL.