Follicular Lymphoma

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Summary

Follicular lymphoma is a slow-growing B-cell cancer that arises from lymph nodes. As the second most common type of non-Hodgkin lymphoma, follicular lymphoma is characterized by the presence of many follicle-like structures seen under the microscope upon biopsy of a lymph node. Classically, follicular lymphoma is caused by a t(14;18) chromosomal translocation that moves the BCL2 gene from chromosome 18 to the heavy chain immunoglobulin locus on chromosome 14. This results in BCL overexpression, preventing apoptosis in B-cells to cause cancer. Clinically, follicular lymphoma follows a slow and indolent course, notable for the finding of waxing and waning lymphadenopathy.