USMLE

Mantle Cell Lymphoma

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Leukemias and Lymphomas
  1. Acute Myelogenous Leukemia (AML)
  2. Acute Promyelocytic Leukemia (APL)
  3. Acute Lymphocytic Leukemia (ALL)
  4. Chronic Myelogenous Leukemia (CML)
  5. Chronic Lymphocytic Leukemia (CLL)
  6. Hairy Cell Leukemia (HCL)
  7. Hodgkin Lymphoma
  8. Burkitt Lymphoma
  9. Diffuse Large B Cell Lymphoma (DLBCL)
  10. Follicular Lymphoma
  11. Mantle Cell Lymphoma
  12. Marginal Zone Lymphoma
  13. Primary CNS Lymphoma (PCNSL)
  14. Acute T-Cell Leukemia/Lymphoma (ATLL)
  15. Mycosis Fungoides / Sezary Syndrome

Summary

Mantle cell lymphoma is a non hodgkin B cell lymphoma that tends to present aggressively in male patients. The genetics of mantle cell lymphoma are due to a t(11;14) translocation of the immunoglobulin heavy chain locus on chromosome 14 to the cyclin D1 gene locus on chromosome 11. This results in an overexpression of cyclin D1, leading to B-cell proliferation and overgrowth. On pathology, expansion of B-cells in the mantle zone of lymph does is seen, with these cancerous B-cells staining positive for CD5.