Mantle Cell Lymphoma



Mantle cell lymphoma is a non hodgkin B cell lymphoma that tends to present aggressively in male patients. The genetics of mantle cell lymphoma are due to a t(11;14) translocation of the immunoglobulin heavy chain locus on chromosome 14 to the cyclin D1 gene locus on chromosome 11. This results in an overexpression of cyclin D1, leading to B-cell proliferation and overgrowth. On pathology, expansion of B-cells in the mantle zone of lymph does is seen, with these cancerous B-cells staining positive for CD5.