USMLE

Bulk-forming Laxatives

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Gastrointestinal Pharm
  1. H2 Blockers (Cimetidine, Ranitidine, Famotidine)
  2. Proton Pump Inhibitors (PPIs)
  3. Misoprostol
  4. Orlistat
  5. Antacids
  6. Bismuth & Sucralfate
  7. Octreotide
  8. Diphenoxylate vs. Loperamide
  9. Ondansetron
  10. Metoclopramide
  11. Bulk-forming Laxatives
  12. Senna
  13. Docusate
  14. Aprepitant

Summary

Psyllium and methylcellulose are two common bulk-forming laxatives. These laxatives work by absorbing water, which softens stool and increases stool bulk. This increased stool bulk stimulates more frequent bowel movements. Too much bulk-forming laxative can result in diarrhea.

Key Points

  • Psyllium, Methylcellulose
    • Mechanism
      • Soluble fiber
        • Promotes peristalsis
    • Clinical Use
      • Laxative for constipation
    • Adverse Effects
      • Diarrhea