USMLE Step 1

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Immunology

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Transplant Rejection

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Acute Transplant Rejection

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Summary

Acute Rejection is a type of transplant rejection that occurs within weeks (acutely) after receiving a new graft. It is caused by T-cells attacking the donor MHCs, and is characterized by vascular damage. Biopsy of the affected organ will reveal dense interstitial lymphocytic infiltrates in the graft. Although serious, acute transplant rejection can be prevented or reversed with immunosuppressive drugs like corticosteroids or calcineurin-inhibiting drugs. 

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