Th17 Cells

10085

Summary

T-Helper Type 17 (Th17) cells are a effector subtype of Helper T-cells with proinflammatory functions. When activated, Th17 cells produce the cytokines IL-17, IL-22, and IL-21, which all have inflammatory effects and stimulate neutrophils. Immunodeficiency of Th17 cells is implicated in hyper-IgE syndrome. 

Key Points

  • T Helper Type 17 (Th17) cells (low yield)
    • Effector subtype of Helper T-cell
    • Coordinate cellular immune response
    • Induced by TGF-beta and IL-6
    • Secretes IL-17, IL-21, and IL-22
      • Inflammatory cytokines that stimulate neutrophils
    • Immunodeficiency of Th17 cells may play a role in Hyper-IgE (Job) syndrome