USMLE

Th17 Cells

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B Cells and T Cells
  1. MHC I
  2. MHC II
  3. B Cells - Overview
  4. B Cells - Activation
  5. Plasma B Cells
  6. Memory B Cells
  7. T Cells - Overview
  8. T Cells - Activation
  9. T Cells - Differentation
  10. Cytotoxic (Killer) T Cells
  11. Helper T Cells - Overview
  12. Th1 Cells
  13. Th2 Cells
  14. Th17 Cells
  15. Regulatory T Cells (Tregs)

Summary

T-Helper Type 17 (Th17) cells are a effector subtype of Helper T-cells with proinflammatory functions. When activated, Th17 cells produce the cytokines IL-17, IL-22, and IL-21, which all have inflammatory effects and stimulate neutrophils. Immunodeficiency of Th17 cells is implicated in hyper-IgE syndrome. 

Key Points

  • T Helper Type 17 (Th17) cells (low yield)
    • Effector subtype of Helper T-cell
    • Coordinate cellular immune response
    • Induced by TGF-beta and IL-6
    • Secretes IL-17, IL-21, and IL-22
      • Inflammatory cytokines that stimulate neutrophils
    • Immunodeficiency of Th17 cells may play a role in Hyper-IgE (Job) syndrome