Th17 Cells
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Summary
T-Helper Type 17 (Th17) cells are a effector subtype of Helper T-cells with proinflammatory functions. When activated, Th17 cells produce the cytokines IL-17, IL-22, and IL-21, which all have inflammatory effects and stimulate neutrophils. Immunodeficiency of Th17 cells is implicated in hyper-IgE syndrome.
Key Points
- T Helper Type 17 (Th17) cells (low yield)
- Effector subtype of Helper T-cell
- Coordinate cellular immune response
- Induced by TGF-beta and IL-6
- Secretes IL-17, IL-21, and IL-22
- Inflammatory cytokines that stimulate neutrophils
- Immunodeficiency of Th17 cells may play a role in Hyper-IgE (Job) syndrome