Summary

T-Helper Type 17 (Th17) cells are a effector subtype of Helper T-cells with proinflammatory functions. When activated, Th17 cells produce the cytokines IL-17, IL-22, and IL-21, which all have inflammatory effects and stimulate neutrophils. Immunodeficiency of Th17 cells is implicated in hyper-IgE syndrome. 

Key Points

• T Helper Type 17 (Th17) cells (low yield)
  • Effector subtype of Helper T-cell
  • Coordinate cellular immune response
  • Induced by TGF-beta and IL-6
  • Secretes IL-17, IL-21, and IL-22
    • Inflammatory cytokines that stimulate neutrophils
  • Immunodeficiency of Th17 cells may play a role in Hyper-IgE (Job) syndrome