USMLE Step 1

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Immunology

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Immunosuppressants

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Basiliximab

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Summary

Basiliximab is an immunosuppressant drug used primarily for preventing transplant rejection. Basiliximab achieves its immunosuppressive effects by binding to and blocking IL-2 receptors. This prevents the growth of all lymphocytes, including T-cells, B-cells and Natural Killer (NK) cells.

Key Points

  • Basiliximab
    • Immunosuppressant drug
      • Used in transplant rejection prophylaxis
    • Mechanism
      • monoclonal antibody against Interleukin-2 (IL-2) receptors
        • Blocked IL-2 signalling impairs growth of all lymphocytes, leading to immunosuppression
    • Adverse Effects (low yield)
      • Edema
      • Hypertension
      • Tremor