Basiliximab
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Immunosuppressants
Summary
Basiliximab is an immunosuppressant drug used primarily for preventing transplant rejection. Basiliximab achieves its immunosuppressive effects by binding to and blocking IL-2 receptors. This prevents the growth of all lymphocytes, including T-cells, B-cells and Natural Killer (NK) cells.
Key Points
- Basiliximab
- Immunosuppressant drug
- Used in transplant rejection prophylaxis
- Mechanism
- monoclonal antibody against Interleukin-2 (IL-2) receptors
- Blocked IL-2 signalling impairs growth of all lymphocytes, leading to immunosuppression
- monoclonal antibody against Interleukin-2 (IL-2) receptors
- Adverse Effects (low yield)
- Edema
- Hypertension
- Tremor
- Immunosuppressant drug