Plasma B Cells
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B Cells and T Cells
- MHC I
- MHC II
- B Cells - Overview
- B Cells - Activation
- Plasma B Cells
- Memory B Cells
- T Cells - Overview
- T Cells - Activation
- T Cells - Differentation
- Cytotoxic (Killer) T Cells
- Helper T Cells - Overview
- Th1 Cells
- Th2 Cells
- Th17 Cells
- Regulatory T Cells (Tregs)
Summary
Plasma B cells are a subset of activated B-lymphocytes. They produce soluble antibodies against specific antigens. On microscopy, plasma B-cells are distinguished by their clock-faced chromatin distribution and eccentric nuclei. Plasma cells are typically found in the bone marrow.
Key Points
- Plasma B Cells
- Effector B-cell produced after B-cell Activation
- Provide humoral immunity by producing antibodies against an antigen
- “Clock face” nuclear chromatin and eccentric (off-center) nucleus
- Eccentric nucleus due to large RER/Golgi secondary to robust antibody production
- Found in bone marrow
- Activated B-lymphocytes migrate from lymphoid tissue back to marrow
- Normally do not circulate in peripheral blood