Medicine & USMLE

IL-10

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Cytokines
  1. TNF-alpha
  2. IL-1
  3. IL-2
  4. IL-3
  5. IL-4
  6. IL-5
  7. IL-6
  8. IL-8
  9. IL-10
  10. IL-12
  11. TGF-beta
  12. IFN-alpha and IFN-beta
  13. IFN-gamma

Summary

Interleukin-10 (IL-10) is a cytokine released by Th2 cells. As one of the primary anti-inflammatory cytokines, IL-10 plays a major role in stopping the inflammatory response, which promotes wound healing.

Key Points

  • Interleukin-10 (IL-10)
    • Secreted by Th2 cells
    • Major anti-inflammatory cytokine
      • Resolution of inflammatory response is important for wound healing
      • Inhibits the production of many pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-2, etc.)
      • Decreases expression of MHC II and Th1 cytokines
      • Inhibits activation of macrophages and dendritic cells