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IL-10

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Summary

Interleukin-10 (IL-10) is a cytokine released by Th2 cells. As one of the primary anti-inflammatory cytokines, IL-10 plays a major role in stopping the inflammatory response, which promotes wound healing.

Key Points

  • Interleukin-10 (IL-10)
    • Secreted by Th2 cells
    • Major anti-inflammatory cytokine
      • Resolution of inflammatory response is important for wound healing
      • Inhibits the production of many pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-2, etc.)
      • Decreases expression of MHC II and Th1 cytokines
      • Inhibits activation of macrophages and dendritic cells