Tertiary Structure
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Protein Structure
Summary
Tertiary structure describes the 3-dimensional structure of a protein, as dictated by side-chain interactions and interactions with water. Specific types of side-chain interactions include hydrogen bonding, electrostatic interactions, and disulfide bonding.
Key Points
- Tertiary Structure
- interactions between side chains (R-groups) and folding in water
- Normally, distant residues interacting (occurs when several secondary structures come together)
- note - NOT PEPTIDE BACKBONE (contrast vs secondary)
- Primary driving force is hydrophilic and hydrophobic interactions
- Non-polar groups face the interior of the protein, polar groups face the exterior of the protein
- But also includes
- Hydrogen bonding
- Electrostatic attraction (ionic/salt bridge)
- Van der Waals forces
- Disulfide bonds (type of covalent bond)
- interactions between side chains (R-groups) and folding in water