Ondansetron
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Gastrointestinal Pharm
- H2 Blockers (Cimetidine, Ranitidine, Famotidine)
- Proton Pump Inhibitors (PPIs)
- Misoprostol
- Orlistat
- Antacids
- Bismuth & Sucralfate
- Octreotide
- Diphenoxylate vs. Loperamide
- Ondansetron
- Metoclopramide
- Bulk-forming Laxatives
- Senna
- Docusate
- Aprepitant
Summary
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Key Points
- Ondansetron
- Mechanism
- Serotonin (5-HT3) antagonist
- Acts in area postrema of medulla (vomiting centers)
- Central-acting antiemetic
- Also acts at peripheral and enteric nerves
- Decrease vagal stimulation to GI tract
- Acts in area postrema of medulla (vomiting centers)
- Serotonin (5-HT3) antagonist
- Clinical Use
- Antiemetic
- Especially in setting of GI-injury (e.g. postoperative, infection) or chemotherapy
- Antiemetic
- Adverse Effects
- Serotonin syndrome
- Any drug that modulates serotonin signaling may lead to serotonin syndrome
- QT interval prolongation
- Risk for Torsades de Pointes
- Headache
- Constipation
- Serotonin syndrome
- Mechanism