USMLE

Scopolamine

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Anticholinergics
  1. Atropine (Homatropine and Tropicamide)
  2. Glycopyrrolate
  3. Hyoscyamine & Dicyclomine
  4. Oxybutynin Solifenacin Tolterodine
  5. Scopolamine

Summary

Scopolamine is a centrally acting muscarinic antagonist that blocks central M1 receptors to help treat motion sickness.

Key Points

  • Scopolamine
    • Mechanism
      • Muscarinic Antagonist
        • Blocks M1 Muscarinic Receptors in CNS
    • Clinical Use
      • Motion sickness (vestibular nausea)
        • Scopolamine patches are widely prescribed to treat seasickness or secondary causes of vestibular nausea (e.g. Meniere’s disease)