Ketamine is an NMDA antagonist in the brain that is used in the induction and maintenance of anesthesia. As a sympathomimetic, it causes a fight-or-flight like response, which can present as an elevated heart rate or blood pressure. Lastly, don’t forget that Ketamine can cause increased intracranial pressure.

Key Points

  • Ketamine
    • Mechanism
      • NMDA receptor antagonist
        • Sympathomimetic
    • Clinical use
      • IV anesthetic
        • Used for induction of anesthesia
    • Side effects
      • Increased ICP