USMLE

Etoposide, Teniposide

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Oncology Pharm
  1. Bleomycin
  2. Dactinomycin, Actinomycin D
  3. Doxorubicin, Daunorubicin
  4. Azathioprine, 6-MP
  5. Cladribine
  6. Cytarabine
  7. Busulfan
  8. Cyclophosphamide, Ifosfamide
  9. Nitrosoureas
  10. Paclitaxel
  11. Vincristine, Vinblastine
  12. Cisplatin, Carboplatin, Oxaliplatin
  13. Etoposide, Teniposide
  14. Irinotecan, Topotecan
  15. Bevacizumab
  16. Erlotinib
  17. Cetuximab, Panitumumab
  18. Imatinib, Dasatinib
  19. Rituximab
  20. Bortezomib, Carfilzomib
  21. Trastuzumab
  22. Dabrafenib, Vemurafenib
  23. Raloxifene and Tamoxifen
  24. Hydroxyurea
  25. Procarbazine

Summary

Etoposide and teniposide are topoisomerase II inhibitors. By inhibiting topoisomerase II, these -posides prevent DNA strand breaks from being repaired and increase the rate of DNA degradation. These drugs are effective in the treatment of cancers, but patients taking them may experience myelosuppression, alopecia, and GI upset. 

Key Points

  • Etoposide, Teniposide
    • Mechanism
      • Inhibit DNA topoisomerase II
        • Increased DNA degradation
    • Clinical use
      • Solid tumors (particularly testicular and small cell lung cancer)
      • Leukemia
      • Lymphomas
      • Solid + wet = all cancers
    • Adverse effects
      • Myelosuppression
      • Alopecia
      • GI upset