Cladribine is a purine analog that is used to treat hairy cell leukemia. Its incorporation into DNA in place of a purine causes premature breaks, and subsequent halting, of DNA synthesis. It can cause numerous adverse effects such as neurotoxicity, nephrotoxicity, and myelosuppression.

Key Points

  • Cladribine
    • Mechanism
      • Purine analog
        • Inhibits DNA polymerase
        • Causes DNA strand breaks
        • Adenosine analog that is resistant to adenosine deaminase (ADA)
    • Clinical Use
      • Hairy cell leukemia
    • Adverse Effects
      • Nephrotoxicity
      • Neurotoxicity
      • Myelosuppression