Cladribine
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Summary
Cladribine is a purine analog that is used to treat hairy cell leukemia. Its incorporation into DNA in place of a purine causes premature breaks, and subsequent halting, of DNA synthesis. It can cause numerous adverse effects such as neurotoxicity, nephrotoxicity, and myelosuppression.
Key Points
- Cladribine
- Mechanism
- Purine analog
- Inhibits DNA polymerase
- Causes DNA strand breaks
- Adenosine analog that is resistant to adenosine deaminase (ADA)
- Purine analog
- Clinical Use
- Hairy cell leukemia
- Adverse Effects
- Nephrotoxicity
- Neurotoxicity
- Myelosuppression
- Mechanism