Paclitaxel
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Oncology Pharm
- Bleomycin
- Dactinomycin, Actinomycin D
- Doxorubicin, Daunorubicin
- Azathioprine, 6-MP
- Cladribine
- Cytarabine
- Busulfan
- Cyclophosphamide, Ifosfamide
- Nitrosoureas
- Paclitaxel
- Vincristine, Vinblastine
- Cisplatin, Carboplatin, Oxaliplatin
- Etoposide, Teniposide
- Irinotecan, Topotecan
- Bevacizumab
- Erlotinib
- Cetuximab, Panitumumab
- Imatinib, Dasatinib
- Rituximab
- Bortezomib, Carfilzomib
- Trastuzumab
- Dabrafenib, Vemurafenib
- Raloxifene and Tamoxifen
- Hydroxyurea
- Procarbazine
Summary
Paclitaxel and other taxanes are chemotherapeutic drugs that work by preventing breakdown of microtubules. This effect is particularly effective against rapidly dividing cells, making paclitaxel a useful tool in treating cancers. One side effect associated with microtubule inhibition is peripheral neuropathy. Other side effects seen include myelosuppression and hypersensitivity.
Key Points
- Paclitaxel / Taxanes
- Mechanism
- Blocks microtubule breakdown
- They do this by hyperstabilizing polymerized microtubules
- Occurs during the M phase of the cell cycle
- Prevents anaphase from occurring
- Toxic to rapidly-dividing cells
- Prevents anaphase from occurring
- Blocks microtubule breakdown
- Clinical Use
- Ovarian and breast cancers
- Adverse Effects
- Peripheral neuropathy
- Myelosuppression (obvious)
- Hypersensitivity
- Mechanism