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Protein Structure

Primary Protein Structure

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Summary

The primary structure of proteins refers to the sequence or chain of amino acids. These amino acids are linked together by peptide bonds.

Key Points

  • Primary Structure
    • sequence of amino acids linked together by covalent peptide (amide) bonds
      • Affects protein orientation via rotation of N-C and C-C bonds 
    • Factors affecting primary structure:
      • Protease cleavage of peptide bonds
      • DNA mutagenesis (different amino acids encoded)
    • Note: Protein denaturation (unfolding, loss of 3D shape) does not alter primary structure
      • primary sequence of amino acids is unchanged