USMLE Step 1

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Pharmacology

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Cardiovascular Pharm

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Fibrates

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Summary

Lorem

Key Points

  • Fibrates
    • Drug Names
      • Gemfibrozil
      • Bezafibrate
      • Fenofibrate
    • Mechanism
      • Activates PPAR-alpha
        • ↓↓↓ triglycerides
          • Induce lipoprotein lipase
        • Decrease VLDL
        • Increase HDL
        • Decrease LDL (usually)
    • Clinical Use
      • Most effective drug for lowering triglycerides
      • Prevents acute pancreatitis
        • Hypertriglyceridemia is an important cause of acute pancreatitis
    • Adverse Effects
      • Myopathy
        • ↑ risk with statins
      • Hepatotoxicity
        • ↑ risk with statins
      • Cholesterol gallstones
        • Via inhibition of cholesterol 7-alpha-hydroxylase