Medicine & USMLE

McCune-Albright Syndrome

  1. Osteosarcoma
  2. McCune-Albright Syndrome
  3. Hexokinase vs Glucokinase
  4. COP I & II and Clathrin
  5. Kartagener Syndrome (Primary Ciliary Dyskinesia)
  6. Familial Adenomatous Polyposis (FAP)
  7. Peutz-Jeghers Syndrome
  8. Cystic Fibrosis Overview
  9. Cystic Fibrosis Complications
  10. Medicare vs Medicaid
  11. Duchenne and Becker Muscular Dystrophy
  12. Yolk Sac Tumor
  13. Rett Syndrome
  14. Fragile X Syndrome
  15. Whipple's Disease
  16. Osteoid Osteoma vs Osteoblastoma
  17. T1 vs T2 MRIs

McCune-Albright Syndrome is caused by a mutation in the GNAS1 gene, which codes for a Gs protein subunit. This mutation is only survivable with mosaicism, as it is lethal if the mutation affects all cells. Clinical findings of McCune-Albright are unilateral cafe-au-lait spots, polyostotic fibrous dysplasia, pathologic bone fractures, lytic holepunch lesions in bone, and endocrinopathies--such as precocious puberty.