Burkitt Lymphoma is a non-Hodgkin lymphoma affecting B-cells.
It is caused by a t(8;14) translocation, moving the c-myc locus on chromosome 8 to the heavily-expressed heavy-chain immunoglobulin locus on chromosome 14. This increases expression of c-myc, an oncogene that inducescell proliferation, eventually leading to cancer.
The endemic form of Burkitt Lymphoma classically presents with a jaw lesion, and is associated with Epstein Barr Virus infections. Sporadic cases are associated with pelvic or abdominal lesions. On biopsy, rapidly proliferating sheets of lymphocytes are interspersed with bright, tingible-body macrophages, a finding often described as a "starry sky appearance".
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