Whipple’s Disease is an malabsorption disorder thought to be caused by Tropheryma whipplei, a gram-positive bacillus.
Infection with T. whipplei is thought to impair fat absorption in the GI tract, and typical symptoms include chronic diarrhea and steatorrhea (yellow, greasy stool), which can subsequently lead to weight loss. In addition to GI manifestations, patients may have neurologic, cardiac, and joint involvement. Biopsy of the small intestine reveals PAS-positive foamy macrophages.
Find Whipple's Disease and more Malabsorption Disorders among Pixorize's visual mnemonics for the USMLE Step 1 and NBME Shelf Exams.