Goodpasture Syndrome

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Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lung alveoli and renal glomeruli.

Specifically, Goodpasture syndrome is caused by antibodies against type IV collagen. Patients typically present with bleeding from the lungs when coughing (hemotysis) and the kidney in the urine (hematuria). Left unmanaged, patients develop rapidly progressive (crescentic) glomerulonephritis, which can lead to kidney failure.

Immunofluorescence (IF) shows a linear pattern of antibodies against the basement membrane.

Find Goodpasture and other Collagen Related Disorders among Pixorize's visual mnemonics for the USMLE Step 1 and NBME Shelf Exams.