Fatty Acid Breakdown (Carnitine Shuttle)
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Fatty Acid Breakdown (Carnitine Shuttle)
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Fatty Acid Breakdown usually occurs in the liver, and it happens in several key steps including the Carnitine Shuttle. This pathway starts with fatty acids and CoA, which are combined to form Acyl-CoA or easel-Croquet. This Acyl-CoA is then shuttled via Carnitine into the mitochondrial matrix, a process that can be inhibited by high levels of Malonyl-CoA. Once inside the matrix, Acyl-CoA Dehydrogenase performs beta-oxidation on the Acyl-CoA, converting it into Acetyl-CoA. Finally, Acetyl-CoA is a versatile molecule used to produce ketone bodies for export, or ATP via the Kreb’s Cycle for intracellular use.