USMLE

Fatty Acid Synthesis (Citrate Shuttle)

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Biochemical Pathways
  1. Glycolysis
  2. Electron Transport Chain (ETC)
  3. Cori Cycle
  4. De Novo Purine Synthesis
  5. De Novo Pyrimidine Synthesis
  6. Purine Salvage
  7. Purine Excretion
  8. Ethanol Metabolism
  9. Pyruvate Metabolism
  10. HMP Shunt (Pentose Phosphate Pathway)
  11. Galactose Metabolism
  12. Sorbitol (Polyol) Pathway
  13. Urea Cycle
  14. Alanine (Cahill) Cycle
  15. Catecholamine Synthesis & Breakdown
  16. Homocysteine Metabolism
  17. Fatty Acid Synthesis (Citrate Shuttle)
  18. Fatty Acid Breakdown (Carnitine Shuttle)
  19. Propionic Acid Pathway
  20. Fructose Metabolism
  21. Regulation by Fructose-2,6-Bisphosphate (F-2,6-BP)
  22. Glycogenesis

Fatty Acid Synthesis is a biochemical pathway which uses the Citrate Shuttle to produce palmitate, a fatty acid, from other molecules.

First, citrate from the mitochondrial matrix is shuttled to the cytosol via the citrate shuttle. This citrate is then converted by ATP citrate lyase into Acetyl CoA.

Afterwards, Acetyl-CoA is turned into Malonyl-CoA via the Vitamin B7 (Biotin)-dependent Acetyl-CoA carboxylase enzyme.

Finally, this Malonyl-CoA is converted into Palmitate, a 16-C fatty acid at the end of this pathway.

Find Fatty Acid Synthesis and more Biochemical Pathways among Pixorize's visual mnemonics for the USMLE Step 1 and NBME Shelf Exams.