Fatty Acid Synthesis (Citrate Shuttle)
Fatty acid synthesis by the body requires several key steps, including the citrate shuttle. Citrate originates in the mitochondrial matrix and is shuttled to the cytosol by the Citrate Shuttle. This citrate is then converted by ATP citrate lyase into Acetyl CoA. Afterwards, Acetyl-CoA is turned into Malonyl-CoA via the biotin-dependent Acetyl-CoA Carboxylase enzyme. Finally, this Malonyl-CoA is used to make Palmitate, the fatty acid at the end of this pathway.