Fatty Acid Synthesis (Citrate Shuttle)


Fatty Acid Synthesis is a biochemical pathway which uses the Citrate Shuttle to produce palmitate, a fatty acid, from other molecules.

First, citrate from the mitochondrial matrix is shuttled to the cytosol via the citrate shuttle. This citrate is then converted by ATP citrate lyase into Acetyl CoA.

Afterwards, Acetyl-CoA is turned into Malonyl-CoA via the Vitamin B7 (Biotin)-dependent Acetyl-CoA carboxylase enzyme.

Finally, this Malonyl-CoA is converted into Palmitate, a 16-C fatty acid at the end of this pathway.

Find Fatty Acid Synthesis and more Biochemical Pathways among Pixorize's visual mnemonics for the USMLE Step 1 and NBME Shelf Exams.