Vitamin E (Tocopherol/Tocotrienol)
Vitamin E (tocopherol, tocotrienol) is a group of fat-soluble vitamins, for which the exact biological function is poorly understood. At high doses, vitamin E can also alter the function of vitamin K, which enhances the effects of the anticoagulant Warfarin. Vitamin E deficiency, however, can cause neurological problems and changes in the appearance of blood cells under the microscope. For the former, the spinocerebellar tract and dorsal columns are commonly affected. For the latter, it specifically can lead to acanthocytosis, a condition characterized by red blood cells with a spiked cell membrane. Vitamin E is itself an antioxidant, so oxidative damage to red blood cells may also result in a hemolytic anemia.