Vitamin B5 (Pantothenic Acid)



Vitamin B5 (Pantothenic Acid) is a water-soluble vitamin which serves a key role in the synthesis of CoA (coenzyme A), a cofactor in many metabolic reactions. It is also plays a role in fatty acid synthesis, as it is a cofactor for the enzyme fatty acid synthase (FAS). Vitamin B5 Deficiency is rare, and primarily presents with symptoms of gastroenteritis (diarrhea), with possible adrenal insufficiency, dermatitis, or alopecia.

Key Points

  • Vitamin B5 (Pantothenic Acid)
    • Essential cofactor for:
      • coenzyme A (CoA)
        • cofactor for acyl transfers
        • key role in first step of TCA cycle (oxaloacetate to citrate)
      • fatty acid synthase
  • Deficiency (low yield)
    • rare, seen in the severely malnourished
      • enteritis/GI distress
      • dermatis, alopecia, and adrenal insufficiency also seen

Find Vitamin B5 and other Vitamins among Pixorize's visual mnemonics for the USMLE Step 1 and NBME shelf exams.