What is Hereditary Spherocytosis? Hereditary Spherocytosis is an intrinsic hemolytic anemia caused by inherited defects in red blood cells. Learn more by hovering over the interactive image and watching our short video reviews. Study smarter with Pixorize. Retain more, gain a deeper understanding, and feel more prepared for your clerkships and the USMLE STEP 1/NBME shelf exams. Get early access to our upcoming releases, giveaways, and more by following us on social media!