Li-Fraumeni Syndrome (LFS)


Li-Fraumeni Syndrome (LFS) is an inherited predisposition to a wide range of cancers.

It is caused by a mutation in TP53, which encodes the p53 tumor suppressor protein. As TP53 is a tumor suppressor gene, it follows the two-hit hypothesis, which states that mutations on both alleles are required for disease. Patients with LFS are born with one dysfunctional copy, and a spontaneous mutation in the other can lead to the development of many cancers.

Cancer types commonly seen in Li-Fraumeni Syndrome affect the SBLA locations: sarcoma, breast, leukemia, and adrenal gland.

Find Li-Fraumeni Syndrome and other Autosomal Dominant Diseases among Pixorize's visual mnemonics for the USMLE Step 1 and NBME Shelf Exams.