Familial Dysbetalipoproteinemia, also called Type III Dyslipidemia, is an autosomal recessive lipid disorder characterized by aninability to remove chylomicron remnants from the blood.
It is caused by defects in Apolipoprotein E (Apo E), which are typically responsible for the deposition of chylomicron remnants into the liver. The resulting chylomicron accumulation, also increases triglyceride levels in the blood. Complications include accelerated atherosclerosis, with myocardial infarctions ("heart attacks") occurring as early as the second decade of life.
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