Large Cell Carcinoma

Large Cell Carcinoma is a subtype of of non-small cell lung cancer (NSCLC), characterized by fast-growing pleomorphic giant cells (large cells) on biopsy.

Patients typically have a history of smoking. Lesions are classically located on the periphery of the lung (although central lesions possible). Large cell carcinoma is associated with gynecomastia and galactorrhea, caused by ectopic production of beta-hCG.

Pathology on tumor biopsies typically reveals pleomorphic giant cells ("large cells"), sometimes referred to as having an "anaplastic" appearance. While prognosis is typically poor, early stage tumors may be amenable to treatment by surgical resection.

Find Large Cell Carcinoma and more Lung Cancer topics among Pixorize's visual mnemonics for the USMLE Step 1 and NBME Shelf Exams.