USMLE

Small Cell Carcinoma

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Lung Cancer
  1. Lung Cancer Overview
  2. Small Cell Carcinoma
  3. Adenocarcinoma
  4. Squamous Cell Carcinoma
  5. Large Cell Carcinoma
  6. Bronchial Carcinoid Tumor

Small Cell Lung Cancer (SCLC), also known as small cell carcinoma or oat cell cancer, is a highly malignant lung cancer of neuroendocrine nature.

Small cell lung cancers produce a number of ectopic hormones, such as ACTH (causing Cushing syndrome) and ADH (causing SIADH). It is also associated with Lambert-Eaton myasthenic syndrome (LEMS), a paraneoplastic syndrome caused by ectopic synthesis of antibodies against voltage-gated calcium channels used by muscle. Other complications can include paraneoplastic encephalitis/myelitis, characterized by the presence of anti-Hu antibodies.

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