Varenicline

Summary

Varenicline is a medication that works as a partial agonist at nicotinic acetylcholine receptors. Clinically, varenicline is used for smoking cessation. It works by diminishing the rewarding effects of nicotine and treating nicotine withdrawal symptoms. Potential side effects of varenicline include GI distress and sleep disturbances, such as insomnia.

Key Points

• Varenicline
  • Mechanism
    • Partial Agonist of Nicotinic ACh Receptor
  • Clinical Use
    • Smoking Cessation
      • Diminishes effects on reward system (reduces cravings)
      • Reduces withdrawal
  • Side Effects
    • GI upset
    • Sleep disturbance (insomnia)