Medicine & USMLE

Vortioxetine

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Psych Drugs (New)
  1. Mirtazapine
  2. Vortioxetine
  3. Bupropion
  4. Trazodone
  5. Vilazodone
  6. Buspirone
  7. Buprenorphine
  8. Neuroleptic Malignant Syndrome (NMS)
  9. Typical Antipsychotics
  10. Naltrexone
  11. Nicotine Replacement Therapies
  12. SSRIs
  13. Varenicline
  14. Naloxone
  15. CNS Stimulants

Summary

Vortioxetine is a medication that works through several mechanisms: It is a 5-HT1A receptor agonist, an inhibitor of 5-HT reuptake, and a 5-HT3 receptor antagonist.

Clinically, vortioxetine is used as an atypical antidepressant to treat major depressive disorder.

Common side effects of vortioxetine include anticholinergic effects, sexual dysfunction, nausea and vomiting, as well as sleep disturbances like insomnia. A rare but serious potential side effect is serotonin syndrome.

Key Points

  • Vortioxetine
    • Mechanism
      • Inhibits 5-HT reuptake
      • 5-HT1A serotonin agonist
      • 5-HT3 serotonin antagonist
    • Clinical Use
      • Treats depression (atypical antidepressant)
    • Side Effects
      • Causes Serotonin Syndrome
        • Especially when used with other serotonin-modulating drugs (i.e. SSRIs, MAOIs, TCA’s)
      • Sleep disturbance
      • Anticholinergic effects
      • Nausea
      • Sexual dysfunction