Medicine & USMLE

Non-Selective Beta Blockers

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Alpha & Beta Blockers (New)
  1. Phentolamine
  2. Phenoxybenzamine
  3. -osin Drugs
  4. Beta-1 Selective Beta Blockers
  5. Non-Selective Beta Blockers
  6. Dual Alpha Beta Blockers
  7. Nebivolol
  8. Clinical Use of Beta Blockers
  9. Side Effects of Beta Blockers

Non-Selective Beta Blockers

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Summary

The non-selective beta blockers are a class of drugs that indiscriminately block beta receptors, including both beta-1 and beta-2 receptors. By blocking beta-1 receptors in the heart, they reduce heart rate and contractility. By blocking beta-2 receptors in the lungs and blood vessels, they can cause bronchoconstriction and vasoconstriction.

Being beta blockers, all drug names for the non-selective beta blockers end in -lol. Specific drug names to remember include nadolol, carteolol, timolol, propranolol, sotalol, and pindolol. Pindolol is unique because it also acts as a partial beta agonist.

Key Points

  • Nonselective Beta-Blockers
    • Drug Names
      • Nadolol
      • Propranolol
      • Timolol
      • Carteolol
      • Pindolol
        • Partial Agonist at Beta Receptors
      • Sotalol
    • Mechanism
      • Blocks Beta-1 Receptors (Beta-1 Antagonist)
        • Decreased HR (Chronotropy and Dromotropy) and Stroke Volume (Inotropy) → Decreased Cardiac Output
      • Blocks Beta-2 Receptors (Beta-2 Antagonist)
        • Bronchoconstriction, Vasoconstriction