Trazodone
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Mental Health Drugs
- Bupropion
- SNRIs
- SSRIs
- MAOIs
- Tricyclic Antidepressants (TCAs)
- Extrapyramidal Symptoms (EPS)
- Lithium
- Typical Antipsychotics
- Atypical Antipsychotics
- Trazodone
- Buspirone
- Mirtazapine
- CNS Stimulants
- Zolpidem
- Benzodiazepines
- Barbiturates
- Neuroleptic Malignant Syndrome (NMS)
- Barbiturates (Old)
- Benzodiazepines (Old)
- Lithium (Old)
- Bupropion (Old)
- SNRIs (Old)
- MAOIs (Old)
- Amphetamines (Old)
- Typical Antipsychotics (Old)
Summary
Trazodone is a medication that is used to treat depression. It is also commonly used to treat insomnia due to its sedating effects.
Side effects of trazodone include sedation and priapism.
Key Points
- Trazodone
- Drug Class
- Atypical Antidepressant
- Trazodone doesn’t fall into other typical antidepressant drug classes. It has a unique mechanism and unique side effects.
- Atypical Antidepressant
- Mechanism
- Blocks reuptake of serotonin
- This allows an increased amount of serotonin to remain in the synaptic cleft
- Blocks alpha and H1 receptors
- Blocks reuptake of serotonin
- Clinical Use
- Depression
- Often used in combination therapy with another antidepressant
- Insomnia
- An off-label use, due to its sedative properties
- Depression
- Side Effects
- Sedation
- Give at night to avoid daytime drowsiness
- Should not be taken with other CNS depressants (benzodiazepines, alcohol, antihistamines, etc.)
- Priapism
- Prolonged painful erection (>2 hours) that can lead to tissue hypoxia and necrosis if not treated immediately
- Medical emergency
- Sedation
- Drug Class