Mirtazapine
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Summary
Mirtazapine is an atypical antidepressant drug.
It works as an selective alpha-2 antagonist, which increases the release of norepinephrine and serotonin. Mirtazapine also blocks 2 subtypes of serotonin receptors: 5HT-2 and 5HT-3. Additionally, mirtazapine is a H1 receptor antagonist.
Side effects of mirtazapine include weight gain, increased appetite, hyperlipidemia, sedation, and dry mouth.
Key Points
- Mirtazapine
- Mechanism
- Blocks Alpha-2 Receptors
- Increases release of norepinephrine (NE)
- Increases release of serotonin (5-HT)
- Blocks 5HT2 and 5HT3 Serotonin Receptors
- Blocks H1 Receptors
- Blocks Alpha-2 Receptors
- Clinical Use
- Treats Depression
- Atypical antidepressant
- Treats Depression
- Side Effects
- Increased appetite
- Causes weight gain
- Used in underweight patients or those with anorexia nervosa
- Causes Sedation
- Used in patients with insomnia
- Increases Serum Cholesterol
- Causes Dry Mouth
- Increased appetite
- Mechanism