-osin Drugs
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Alpha & Beta Blockers (New)
- Phentolamine
- Phenoxybenzamine
- -osin Drugs
- Beta-1 Selective Beta Blockers
- Non-Selective Beta Blockers
- Dual Alpha Beta Blockers
- Nebivolol
- Clinical Use of Beta Blockers
- Side Effects of Beta Blockers
Summary
The -osin drugs include the drug names prazosin, terazosin, doxazosin, and tamsulosin. These drugs work as selective alpha-1 blockers. Clinically, these drugs are most commonly used to treat BPH. Prazosin may be used to treat PTSD, and all -osin drugs except tamsulosin may also be used to treat hypertension. Side effects of the -osin drugs include first-dose orthostatic hypotension, dizziness and headaches.
Key Points
- Alpha-1 Blockers (-osin Ending)
- Drug Names
- -osin ending
- Prazosin
- Terazosin
- Doxazosin
- Tamsulosin
- -osin ending
- Mechanism
- Alpha-1 Antagonist
- Major effect is relaxation of smooth muscle (e.g. blood vessels, urinary tract)
- Alpha-1 Antagonist
- Clinical Use
- Treats Benign Prostatic Hyperplasia (BPH)
- Relaxation of smooth muscle in prostate can relieve urinary obstruction
- Treats Hypertension (except Tamsulosin)
- Relaxation of smooth muscle in blood vessels causes vasodilation, reducing systemic vascular resistance and blood pressure
- Tamsulosin is selective for alpha-1 receptors on the prostate, and spares the vascular smooth muscle
- Treats PTSD (Prazosin)
- May be used to prevent catecholamine signaling at alpha-1 receptors, reducing arousal
- Treats Benign Prostatic Hyperplasia (BPH)
- Side Effects
- 1st-Dose Orthostatic Hypotension
- Often presents as lightheadedness or syncope, especially after first dose
- Dizziness
- Headache
- 1st-Dose Orthostatic Hypotension
- Drug Names