Medicine & USMLE

Milrinone

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Cardio Drugs - Other
  1. Nitrates (Nitroglycerin, Isosorbide)
  2. Nitroglycerin Administration
  3. Digoxin Overview
  4. Digoxin Toxicity
  5. Ranolazine
  6. Milrinone
  7. Epinephrine
  8. Norepinephrine
  9. Dopamine
  10. Dobutamine
  11. Isoproterenol
  12. Atropine

Summary

Milrinone is a PDE inhibitor that works by causing positive inotropy and vasodilation.

It is used to treat heart failure, but is only recommended for short term use due to its potential side effects.

These side effects include hypotension and arrhythmias.

Key Points

  • Milrinone (Primacor)
    • Drug Class
      • Phosphodiesterase Inhibitor
        • Milrinone is a phosphodiesterase-3 inhibitor
    • Mechanism
      • Positive inotrope (increases contractility)
      • Vasodilation
        • Relaxes the smooth muscle in the blood vessel walls
    • Clinical Use
      • Heart failure
        • Only for short-term use
        • Last resort medication
    • Side Effects
      • Hypotension
        • Closely monitor blood pressure during administration
      • Arrhythmias
        • Closely monitor cardiac rhythm during administration