Blood Clotting
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Cardiovascular
- Cardiovascular Overview
- CO2 Transport
- Heart
- Cardiac Impulse
- Blood Pressure
- Arteries and Arterioles
- Veins and Venules
- Capillaries
- Circulation
- Blood
- Hemoglobin
- Blood Clotting
- Blood Clotting (note: not high yield)
- Function
- Minimize blood loss and facilitate healing after injury
- Process
- Step 1: Platelets form a plug
- Collagen outside of blood vessel chemically interacts with platelets and causes them to stick together (coagulate) at damage site
- Prevents blood flow out of vessel
- Bound platelets and endothelial cells release signals to recruit more platelets
- Step 2: Fibrin forms a mesh
- Platelet aggregation activates clotting factors
- Cascade of activated factors called the Coagulation Cascade
- Culminates in production of thrombin, which converts fibrinogen in plasma to fibrin
- Fibrin strands polymerize and form mesh to hold platelets together, reinforces platelet plug
- Platelet aggregation activates clotting factors
- Step 1: Platelets form a plug
- Function